Document Type
Poster Session
Department
Biomedical Science and Engineering
Faculty Mentor
Daniel Moore, PhD
Keywords
ADR, allergies, penicillin, beta-lactams, genetics
Abstract
Hypersensitivity reactions can be sudden and are often fatal. Many of these reactions occur as a result of allergies to prescribed medication. Adverse drug reactions or (ADR’s) were show in a recent study to affect over 6% of hospitalized patients and resulted in over 100,000 deaths a year in the US alone. This poster will review the importance of understanding genetic predisposition, through articles about possible genetic causes of allergies to penicillin and other beta-lactams. Changes in a specific HLA gene located on chromosome 6 showed a correlation to penicillin reactions in over 600,000 participants. Another study found a conclusive relationship between 42 scientific articles that focus on the role the human genome plays ADR’s out of the more than 3000 they scanned. The intent is to see what common biological pathways come up as factors in these articles that focus on hypersensitivity reactions and to compare them to one another. In doing this they concluded that there in a strong correlation with the HLA region producing IR against penicillin.
Open Access?
1
Included in
Allergy and Immunology Commons, Biotechnology Commons, Genetics and Genomics Commons, Laboratory and Basic Science Research Commons, Pharmacology Commons
Importance of Understanding Genetic Predisposition
Hypersensitivity reactions can be sudden and are often fatal. Many of these reactions occur as a result of allergies to prescribed medication. Adverse drug reactions or (ADR’s) were show in a recent study to affect over 6% of hospitalized patients and resulted in over 100,000 deaths a year in the US alone. This poster will review the importance of understanding genetic predisposition, through articles about possible genetic causes of allergies to penicillin and other beta-lactams. Changes in a specific HLA gene located on chromosome 6 showed a correlation to penicillin reactions in over 600,000 participants. Another study found a conclusive relationship between 42 scientific articles that focus on the role the human genome plays ADR’s out of the more than 3000 they scanned. The intent is to see what common biological pathways come up as factors in these articles that focus on hypersensitivity reactions and to compare them to one another. In doing this they concluded that there in a strong correlation with the HLA region producing IR against penicillin.
