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Document Type
Oral Presentation
Faculty Mentor
Sergey Ryzhov
Abstract
Out of all U.S. deaths 32.3% are directly attributed to Cardiovascular Disease. The cardiomyocytes and endothelial cell dysfunction are affected by the production of microparticles which have implications within the cellular process of signal transduction, cell-to-cell interaction, membrane trafficking, and cellular metabolism. Specifically the functional role in cardiovascular biology and disease can be seen through the paracrine hypothesis of cardiac progenitor cells having a possible direct differentiation that contributes to improved heart function via pro-angiogenic and cardio-protective pathways. The autographing of the Great Saphenous Vein during Coronary Artery Bypass Grafting Surgery is of great interest regarding the production of microparticles and has been elucidated and enumerated via fluorescence activated cell sorting Flow Cytometry.
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Christopher Parlett Presentation Transcript
Open Access?
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Effect of Cardiac Surgery on Microparticle Production
Out of all U.S. deaths 32.3% are directly attributed to Cardiovascular Disease. The cardiomyocytes and endothelial cell dysfunction are affected by the production of microparticles which have implications within the cellular process of signal transduction, cell-to-cell interaction, membrane trafficking, and cellular metabolism. Specifically the functional role in cardiovascular biology and disease can be seen through the paracrine hypothesis of cardiac progenitor cells having a possible direct differentiation that contributes to improved heart function via pro-angiogenic and cardio-protective pathways. The autographing of the Great Saphenous Vein during Coronary Artery Bypass Grafting Surgery is of great interest regarding the production of microparticles and has been elucidated and enumerated via fluorescence activated cell sorting Flow Cytometry.
