Article - Campus-Only Access
American Journal of Respiratory Cell and Molecular Biology
Lead Chromate, Neoplastic Transformation, Bronchial Epithelial Cells
Particulate hexavalent chromium (Cr(VI)) is a well-established human
lung carcinogen with widespread exposure among people in
occupational settings and the general public. However, no studies
have examined the chromate-induced malignant transformation
of human lung epithelial cells, its predominant target. Human
papillomavirus–immortalized human bronchial epithelial (BEP2D)
cells were used to better understand the mechanisms involved
inhumanbronchial carcinogenesis inducedby particulate chromate.
We found that aneuploid cells increased in a concentrationdependent
manner after chronic exposure to lead chromate.
Xie, H., Holmes, A., Wise, S., Huang, S., Peng, C., & Wise, J. (2007). Neoplastic transformation of human bronchial cells by lead chromate particles. American Journal Of Respiratory Cell And Molecular Biology, 37(5), 544-552.