Document Type

Article - Campus-Only Access

Publication Date

11-2007

Publication Title

American Journal of Respiratory Cell and Molecular Biology

Keywords

Lead Chromate, Neoplastic Transformation, Bronchial Epithelial Cells

Abstract

Particulate hexavalent chromium (Cr(VI)) is a well-established human
lung carcinogen with widespread exposure among people in
occupational settings and the general public. However, no studies
have examined the chromate-induced malignant transformation
of human lung epithelial cells, its predominant target. Human
papillomavirus–immortalized human bronchial epithelial (BEP2D)
cells were used to better understand the mechanisms involved
inhumanbronchial carcinogenesis inducedby particulate chromate.
We found that aneuploid cells increased in a concentrationdependent
manner after chronic exposure to lead chromate.

Comments

Copyright American journal of respiratory cell and molecular biology 2007

http://www.atsjournals.org/journal/ajrccm


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