Date of Award
Professor Elizabeth Ehrenfeld, Ph.D
inflammatory bowl diease, Crohn's
Crohn’s disease is a form of inflammatory diseases of the alimentary canal, usually most affecting the small intestine. This disease may affect over 700,000 people in the United States alone, while the cause remains somewhat of a mystery. This literature review will explore the role of two specific genes (NOD2/CARD15, ATG16l1) and how they may affect the pathogenicity of Crohn’s. Both the CARD15/NOD2 and ATG16l1 genes have specific functions in immune and inflammatory response. Studies using both empirical data and in vivo laboratory results the CARD15/NOD2 gene has been found to encode a nucleotide-binding oligomerizationdomain which identifies a specific component of bacterial cell walls, thus playing an important part in innate immunity. The ATG16L1 gene has been shown to regulate autophagocytosisin cells, a function which likely plays a role in the inflammatory response experienced by most Crohn’s patients. The function of both these genes should show a role in how an inflammation of the bowel may occur in patients.
Tibbetts, Thomas J., "Effects of NOD2/CARD15 and ATG16L1 on Crohn’s Pathogenicity" (2014). Thinking Matters. 32.