Start Date

April 2021

Document Type

Poster Session

Department

Biomedical Science and Engineering

Faculty Mentor

Daniel Moore, PhD

Keywords

ADR, allergies, penicillin, beta-lactams, genetics

Abstract

Hypersensitivity reactions can be sudden and are often fatal. Many of these reactions occur as a result of allergies to prescribed medication. Adverse drug reactions or (ADR’s) were show in a recent study to affect over 6% of hospitalized patients and resulted in over 100,000 deaths a year in the US alone. This poster will review the importance of understanding genetic predisposition, through articles about possible genetic causes of allergies to penicillin and other beta-lactams. Changes in a specific HLA gene located on chromosome 6 showed a correlation to penicillin reactions in over 600,000 participants. Another study found a conclusive relationship between 42 scientific articles that focus on the role the human genome plays ADR’s out of the more than 3000 they scanned. The intent is to see what common biological pathways come up as factors in these articles that focus on hypersensitivity reactions and to compare them to one another. In doing this they concluded that there in a strong correlation with the HLA region producing IR against penicillin.

Open Access?

1

Share

COinS
 
Apr 30th, 12:00 AM

Importance of Understanding Genetic Predisposition

Hypersensitivity reactions can be sudden and are often fatal. Many of these reactions occur as a result of allergies to prescribed medication. Adverse drug reactions or (ADR’s) were show in a recent study to affect over 6% of hospitalized patients and resulted in over 100,000 deaths a year in the US alone. This poster will review the importance of understanding genetic predisposition, through articles about possible genetic causes of allergies to penicillin and other beta-lactams. Changes in a specific HLA gene located on chromosome 6 showed a correlation to penicillin reactions in over 600,000 participants. Another study found a conclusive relationship between 42 scientific articles that focus on the role the human genome plays ADR’s out of the more than 3000 they scanned. The intent is to see what common biological pathways come up as factors in these articles that focus on hypersensitivity reactions and to compare them to one another. In doing this they concluded that there in a strong correlation with the HLA region producing IR against penicillin.

 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.

 
blog comments powered by Disqus