Presentation Title

The Genes of Pain

Start Date

30-4-2021 12:00 AM

Document Type

Poster Session

Department

Biological Sciences

Faculty Mentor

Daniel Moore, PhD

Keywords

polymorphisms, pain sensitivity, mutation

Abstract

Pain is an important defense mechanism that protects us from environmental factors that might harm us. Our body's response to pain helps us to avoid injury. However, constant pain is a problem. Management of constant pain is an important area of research. Studies have shown that genetic variation contributes to pain sensitivity.

Numerous pain-related genes and their functional polymorphisms (CYP450, MOR-1, COMT, GCH1, etc.) have been identified in the past ten years. In particular, three opioid receptors (OPRM, OPRD and OPRK) are associated with pain sensitivity. One of the most studied human functional polymorphisms is the debrisoquine/sparteine polymorphism of CYP2D6 (encoding the P450 2D6 enzyme). CYP2D6 is an important metabolic gene associated with the metabolism of many of opioid receptors including codeine, hydrocodone, and tramadol.

A complete lack of sensitivity to pain is a dangerous genetic mutation that can lead to the premature death of an individual. A total loss of pain has been seen in six distinct rare hereditary syndromes, called the ‘channelopathy-associated insensitivity to pain’.

This poster summarizes recent research into pain sensitivity genes. A better understanding of genes that contribute to pain sensitivity could lead to better ways of managing constant pain.

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Apr 30th, 12:00 AM

The Genes of Pain

Pain is an important defense mechanism that protects us from environmental factors that might harm us. Our body's response to pain helps us to avoid injury. However, constant pain is a problem. Management of constant pain is an important area of research. Studies have shown that genetic variation contributes to pain sensitivity.

Numerous pain-related genes and their functional polymorphisms (CYP450, MOR-1, COMT, GCH1, etc.) have been identified in the past ten years. In particular, three opioid receptors (OPRM, OPRD and OPRK) are associated with pain sensitivity. One of the most studied human functional polymorphisms is the debrisoquine/sparteine polymorphism of CYP2D6 (encoding the P450 2D6 enzyme). CYP2D6 is an important metabolic gene associated with the metabolism of many of opioid receptors including codeine, hydrocodone, and tramadol.

A complete lack of sensitivity to pain is a dangerous genetic mutation that can lead to the premature death of an individual. A total loss of pain has been seen in six distinct rare hereditary syndromes, called the ‘channelopathy-associated insensitivity to pain’.

This poster summarizes recent research into pain sensitivity genes. A better understanding of genes that contribute to pain sensitivity could lead to better ways of managing constant pain.

 

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