Regulation of Phosphatidylinositol 4-kinase III alpha Complex Formation in B Cells and its Role in Autoantibody Production

Author

Michaela M. Sangillo MS, University of Southern Maine

Date of Award

5-13-2015

Call Number

QH601 .S26 2015

Document Type

Open Access Thesis

Degree Name

Master of Science (MS)

Department

Applied Medical Science

First Advisor

Stephen C. Pelsue

Second Advisor

Samuel M. Duboise

Third Advisor

Ah-Kau Ng

Keywords

Autoimmune disorders, Hepatitis C, viruses

Abstract

The plasma membrane protein Efr3b, the Tetratricopeptide domain repeat 7 (Ttc7), and the kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIa) are found to form a complex a the plasma membrane. This complex is thought to play a role regulating the PI4P pools at the plasma membrane, which is imperative to membrane identity and vesicle transport.

Recommended Citation

Sangillo, Michaela M. MS, "Regulation of Phosphatidylinositol 4-kinase III alpha Complex Formation in B Cells and its Role in Autoantibody Production" (2015). All Student Scholarship. 93.
https://digitalcommons.usm.maine.edu/etd/93