A Research-Based Laboratory Course in Organic Chemistry

Document Type


Publication Date


Publication Title

Journal of Chemical Education


Second-Year Undergraduate, Laboratory Instruction, Hands-On Learning / Manipulatives, Combinatorial Chemistry


The development, implementation, evolution, and evaluation of a unique approach to laboratory instruction in organic chemistry is described. The new course involves a multistep synthesis of group 14 metalloles. The program employs a combinatorial strategy to offer every student a different group 14 metallole as their personal synthetic target. Evaluation by faculty, students, and external evaluators indicates that this approach is superior to the more traditional laboratory course it replaced. Using this combinatorial approach as a model, any research project that involves a synthetic component can be incorporated into an undergraduate laboratory curriculum.


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