Date of Award
Professor Elizabeth Ehrenfeld
Diabetes, Inactivation of Insulin
Type 2 Diabetes (T2D) is the most common form of diabetes mellitus which affects approximately 8.3% of the popula@on (diabetes.org 2013). T2D is most oDen brought on by reduced sensi@vity to insulin receptors. This is thought to be caused by a muta@on in the gene Insulin Receptor Substrate-‐ 1 (IRS-‐1). It is the suppression of IRS-‐1 that leads to inac@va@on of signaling molecules insulin signaling pathways causing insulin resistance (Victor D. H. et al). This literature review will focus on the major mechanisms of inhibi@on of the insulin signaling pathways.
Cotton, JaLise Maree, "Inhibition Mechanisms of Type 2 Diabetes" (2014). Thinking Matters. 8.