Author

Jason Stewart

Date of Award

2015

Document Type

Open Access Thesis

Degree Name

Master of Science (MS)

Department

Applied Medical Science

First Advisor

Hong Xie

Second Advisor

John Wise Sr.

Third Advisor

Ah-Kau Ng

Keywords

Human exposure, water solubility, environmental contamination, anthropogenic sources

Abstract

Hexavalent chromium (Cr(VI)) compounds are well-established human lung carcinogens. Arsenic (As) is a well documented human carcinogen with long term exposure to AS in drinking water being linked to lung, kidney and liver cancer, among others. Co-exposure studies are now becoming more common as humans are not exposed to just one toxicant at a time. This is the first study to investigate the effects of co-exposure with arsenic and soluble or particulate Cr(Vi) compounds in human lung fibroblasts.