Date of Award
Open Access Thesis
Master of Biological Science (MBioSci)
John P. Wise
Chromosome aberrations, cancer, cellular genome
Epidemiology studies of human workers exposed to particulate cobalt have found increased incidence of lung cancer. A hallmark of lung cancer, chromosome instability(CIN) manifests as either numerical or structural abnormalities, which are thought to result from unrepaired or miss-repaired DNA double strand breaks, homologous recombination (HR) and non homologous end joining (NHEJ). Previous studies have shown that HR protects cells against metal induced CIN while NHEJ does not. We investigated whether this outcome occurs for cobalt.
Raph, Sean, "Effects of Cobalt on DNA Double Strand Break Repair-Deficient Cells" (2015). All Theses & Dissertations. 122.
Available for download on Friday, March 23, 2018