Author

Sean Raph

Date of Award

2015

Document Type

Open Access Thesis

Degree Name

Master of Biological Science (MBioSci)

Department

Biology

First Advisor

John P. Wise

Second Advisor

David Champlin

Third Advisor

James Graves

Keywords

Chromosome aberrations, cancer, cellular genome

Abstract

Epidemiology studies of human workers exposed to particulate cobalt have found increased incidence of lung cancer. A hallmark of lung cancer, chromosome instability(CIN) manifests as either numerical or structural abnormalities, which are thought to result from unrepaired or miss-repaired DNA double strand breaks, homologous recombination (HR) and non homologous end joining (NHEJ). Previous studies have shown that HR protects cells against metal induced CIN while NHEJ does not. We investigated whether this outcome occurs for cobalt.

Available for download on Friday, March 23, 2018

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