Date of Award
2015
Call Number
RA1231.C65 R36 2015
Document Type
Open Access Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
John P. Wise
Second Advisor
David Champlin
Third Advisor
James Graves
Keywords
Chromosome aberrations, cancer, cellular genome, Biology
Abstract
Epidemiology studies of human workers exposed to particulate cobalt have found increased incidence of lung cancer. A hallmark of lung cancer, chromosome instability(CIN) manifests as either numerical or structural abnormalities, which are thought to result from unrepaired or miss-repaired DNA double strand breaks, homologous recombination (HR) and non homologous end joining (NHEJ). Previous studies have shown that HR protects cells against metal induced CIN while NHEJ does not. We investigated whether this outcome occurs for cobalt.
Recommended Citation
Raph, Sean MS, "Effects of Cobalt on DNA Double Strand Break Repair-Deficient Cells" (2015). All Student Scholarship. 122.
https://digitalcommons.usm.maine.edu/etd/122
